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Drug Metabolism Reviews Volume 54, 2022 - Issue 3
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Review Articles

Biotransformation novel advances – 2021 year in review

S. Cyrus Khojasteha Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-8385-9288
ORCID Icon,
Upendra A. Argikarb Non-clinical Development, Bill and Melinda Gates Medical Research Institute, Cambridge, MA, USAORCID Iconhttps://orcid.org/0000-0002-0939-0813
ORCID Icon,
Sungjoon Choa Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USAORCID Iconhttps://orcid.org/0000-0003-1215-9759
ORCID Icon,
Rachel Crouchc Department of Pharmaceutical Sciences, Lipscomb University College of Pharmacy and Health Sciences, Nashville, TN, USAORCID Iconhttps://orcid.org/0000-0002-4525-6072
ORCID Icon,
Carley J. S. Heckd Medicine Design, Pfizer Worldwide Research, Development and Medical, Groton, CT, USAORCID Iconhttps://orcid.org/0000-0002-6842-3670
ORCID Icon,
Kevin M. Johnsona Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USAORCID Iconhttps://orcid.org/0000-0003-0479-4242
ORCID Icon,
Amit S. Kalgutkare Medicine Design, Pfizer Worldwide Research, Development and Medical, Cambridge, MA, USAORCID Iconhttps://orcid.org/0000-0001-9701-756X
ORCID Icon,
Lloyd Kingf Quantitative Drug Discovery, UCB Biopharma UK, Slough, UKORCID Iconhttps://orcid.org/0000-0002-3301-7533
ORCID Icon,
Hlaing (Holly) Mawg Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USAORCID Iconhttps://orcid.org/0000-0002-4051-7958
ORCID Icon,
Herana Kamal Seneviratneh Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USAORCID Iconhttps://orcid.org/0000-0002-7221-7060
ORCID Icon,
Shuai Wanga Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USAORCID Iconhttps://orcid.org/0000-0002-3282-1343
ORCID Icon,
Cong Weii Drug Metabolism and Pharmacokinetics, Biogen Inc, Cambridge, MA, USAORCID Iconhttps://orcid.org/0000-0003-2310-9255
ORCID Icon,
Donglu Zhanga Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USA
&
Klarissa D. Jacksonj Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, Chapel Hill, NC, USAORCID Iconhttps://orcid.org/0000-0002-9388-9800
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Pages 207-245 | Received 03 May 2022, Accepted 29 Jun 2022, Published online: 30 Aug 2022
 
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Abstract

Biotransformation field is constantly evolving with new molecular structures and discoveries of metabolic pathways that impact efficacy and safety. Recent review by Kramlinger et al. (Citation2022) nicely captures the future (and the past) of highly impactful science of biotransformation (see the first article). Based on the selected articles, this review was categorized into three sections: (1) new modalities biotransformation, (2) drug discovery biotransformation, and (3) drug development biotransformation ().

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