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Abstract
The application of Pluronic F127 as injectable gel-forming solution is limited by poor mechanical properties. The purpose of this study was to develop low viscosity formulations at ambient temperature that undergo a transition to gel under physiological conditions. Mixtures of Pluronic F127 and poly(vinyl alcohol) with different compositions were prepared in aqueous solutions and their in-situ gelation was investigated by dynamic light scattering and rheology. The results obtained for different formulations showed synergistic effects of polymer mixtures in aqueous media and their properties can be tuned by varying polymer concentration, system composition or changing temperature.
Notes
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