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Experimental Aging Research
An International Journal Devoted to the Scientific Study of the Aging Process
Volume 34, 2007 - Issue 1
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Original Articles

The Influence of Age on Intestinal Dipeptidyl Peptidase IV (DPP IV/CD26), Disaccharidases, and Alkaline Phosphatase Enzyme Activity in C57BL/6 Mice

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Pages 49-62 | Received 16 May 2006, Accepted 06 Aug 2006, Published online: 11 Jan 2008
 

Abstract

The objective of this study was to determine and describe the age-related changes in intestinal brush border membrane enzyme activities that occur in C57Bl/6 mice. Specifically, jejunal, duodenal, and ileal dipeptidyl peptidase IV/CD26, disaccharidase (lactase, sucrase, and maltase), and alkaline phosphatase activities were determined. A significant correlation between analyzed intestinal brush border membrane enzyme activities and animal age was found. Our study revealed that intestinal dipeptidyl peptidase IV/CD26, lactase, sucrase, maltase, and alkaline phosphatase activities decline significantly with age (p < .05). Nevertheless, the horizontal (duodenum to ileum) enzyme activity patterns are not affected by age.

Acknowledgments

The research was supported by the Ministry of Science, Education and Sports of the Republic of Croatia, scientific project number 0062045. The authors gratefully acknowledge Professor Zeljko Kucan for critical reading of the manuscript and for his very valuable suggestions. They thank Mrs. Dolores Kovacic for the excellent technical assistance.

Notes

Note. Data are expressed as mean±standard deviation. n = 6–8 mice per group.

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