Light to Moderate Alcohol Consumption is Associated with S100β and Amyloid Beta Levels in Healthy Older Adults

Abstract

Heavy alcohol consumption has been associated with several adverse neurocognitive outcomes in older adults, though little is known about lower consumption levels. No study has investigated the associations between S100β and amyloid beta (Aβ) serum levels (biomarkers that provide evidence of neurological pathology) and light to moderate alcohol consumption in healthy older adults without neurological conditions. Thirty-five healthy older adults underwent neuropsychological testing and fasting blood draw with subsequent serum S100β and Aβ 1–40 level quantification. Increased S100β levels were associated with increased frequency of alcohol consumption and increased total monthly consumption of alcohol. Increased Aβ levels were associated with increased quantity of alcohol consumption. Further work investigating possible mechanisms is needed, particularly longitudinal studies and studies employing neuroimaging.

Notes

Note

∗p > .05 level (two-tailed). Frequency = number of drinking days over the past 30 days; typical = average drinks per drinking day; total consumption = frequency of drinking multiplied by average drinks per drinking day. Cohen's d values of 0.2, 0.5, and 0.8 (in either direction) are the minimum thresholds for a

^a small effect

^b medium effect

^c large effect sizes, respectively (Cohen, 1992).