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Experimental Aging Research
An International Journal Devoted to the Scientific Study of the Aging Process
Volume 34, 2008 - Issue 4
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Original Articles

Modulatory Role of Glutathione Monoester in Augmenting Age-Associated Neuronal Antioxidant System

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Pages 419-436 | Received 15 Dec 2006, Accepted 20 Mar 2007, Published online: 22 Aug 2008
 

Abstract

An ever-increasing number of reports show the involvement of free radicals in the functional and structural changes occurring in the brain as a part of the normal aging process. This study aimed to assess the potential efficacy of glutathione monoester (GME) when administered intraperitoneally (12 mg/kg body weight) for 20 days on memory and the antioxidant defense system and lipid peroxidation in discrete brain regions such as cortex, striatum, and hippocampus of young and aged rats. Age-associated decline in memory and activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione, vitamin E, and vitamin C, and elevated levels of lipid peroxidation and oxidized glutathione, were observed in all the brain regions studied (p < .001). GME administration was effective in restoring the antioxidant status and in decreasing lipid peroxidation level in aged rat brain regions.

Notes

Note. Values are expressed as mean±SD for six rats in each group. a, compared with young control; b, compared with young treated; c, compared with aged control. The symbols $, #, and ∗represent statistical significance at p < .001, p < .01, and p < .05, respectively.

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