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Experimental Aging Research
An International Journal Devoted to the Scientific Study of the Aging Process
Volume 34, 2008 - Issue 4
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Original Articles

Age-Related Changes in Tissue and Plasma Zinc Levels: Modulation by Exogenously Administered Melatonin

, &
Pages 453-462 | Received 27 Sep 2006, Accepted 27 Feb 2007, Published online: 22 Aug 2008
 

Abstract

Melatonin (MEL) is synthesized mainly in the pineal gland and derived from 5-hydroxytryptophan (5-HTP). Zinc (Zn) is one of the most important trace elements in the body. Zn and MEL levels are changed with aging. The aim of this study was to investigate the age-related changes of tissue and plasma Zn levels and effect of MEL administration on these parameters. Male wistar rats received for 3 weeks subcutaneous injection of MEL (10 mg/kg). Kidney and pancreas Zn levels in old rats were significantly lower than middle-aged group. Spleen, small intestine, and plasma Zn levels were not different in middle-aged and old rats. On the other hand, MEL treatment increased Zn levels of small intestine and plasma in middle-aged rats. However, kidney, spleen, and pancreas Zn levels were unaffected by MEL treatment.

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Notes

a p < .0001 compared to same age control group.

b p < .0001 compared to middle-aged MEL-treated group.

c p < .001 compared to same age control group.

d,f,h p < .001 compared to middle-aged MEL-treated group.

e,g p < .001 compared to middle-aged control group.

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