Glomerular basement membrane changes in aging nondiabetic and diabetic guinea pigs

Paul H. Langner Departments of Comparative Medicine, Anatomy, and Pathology, College of Medicine, The Milton S. Hershey Medical Center of The Pennsylvania Statae University, Hershey, PA, 17033, U.S.A.

C. Max Lang Departments of Comparative Medicine, Anatomy, and Pathology, College of Medicine, The Milton S. Hershey Medical Center of The Pennsylvania Statae University, Hershey, PA, 17033, U.S.A.

Suraj B. Singh Departments of Comparative Medicine, Anatomy, and Pathology, College of Medicine, The Milton S. Hershey Medical Center of The Pennsylvania Statae University, Hershey, PA, 17033, U.S.A.

B. L. Munger Departments of Comparative Medicine, Anatomy, and Pathology, College of Medicine, The Milton S. Hershey Medical Center of The Pennsylvania Statae University, Hershey, PA, 17033, U.S.A.

Arthur B. Abt Departments of Comparative Medicine, Anatomy, and Pathology, College of Medicine, The Milton S. Hershey Medical Center of The Pennsylvania Statae University, Hershey, PA, 17033, U.S.A.

Abstract

Glomerular hyperplasia and thickening or the glomerular basement membrane increase with age in humans and animals. This glomerulopathy can be enhanced by hyperglycemic conditions such as diabetes mellitus. When diabetic guinea pigs were examined by fluorescent microscopy, deposits of a substance similar to immunoglobulin G (IgG) were seen. Comparison with nondiabetic age-matched control animals suggest that glomerulopathy is related to aging, and can be further enhanced by hyperglycemia.

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Glomerular basement membrane changes in aging nondiabetic and diabetic guinea pigs

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Glomerular basement membrane changes in aging nondiabetic and diabetic guinea pigs

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