Modified mantel-haenszel procedures for matched pairs

Abstract

In the prospective study of a finely stratified population, one individual from each stratum is chosen at random for the “treatment” group and one for the “non-treatment” group. For each individual the probability of failure is a logistic function of parameters designating the stratum, the treatment and a covariate. Uniformly most powerful unbiased tests for the treatment effect are given. These tests are generally cumbersome but, if the covariate is dichotomous, the tests and confidence intervals are simple. Readily usable (but non-optimal) tests are also proposed for poly-tomous covariates and factorial designs. These are then adapted to retrospective studies (in which one “success” and one “failure” per stratum are sampled). Tests for retrospective studies with a continuous “treatment” score are also proposed.

Keywords:

• matching
• logistic regression
• permutation tests