A scenario for sequential experimentation

Abstract

This tutorial emphasizes the role of differecnt types of experimental design in a multi–stage investigation. In the initial phase group–screeningo can reveal the really important factors among hundreds of factors. Resooulution III designs are useful immediately after the screening phase, to investigate firstorder effects, provided higher–order effects are unimportants, i.e., validation is necessary. Resulotion IV designs may explain why a first–order model is not valid, i.e., they may yield unbiased estimators of sums of interactions. Resolution V designs yield unbiased estimators of the individual two–factor interactions. They can be easily extended to central composite designs to estimate pure quadratic effects of quantitative factors. Smaller steps are also possible, e.g. one run at a time, for model discrimination and calibration.

Keywords:

• Multistage
• sequential
• screening
• resolution
• validation
• interactions
• response surface