High Incidence of Hb D-Los Angeles [β121(GH4)Glu→Gln] in Denizli Province, Aegean Region of Turkey

Erol Ö. Atalay Department of Biophysics, Medical Faculty, Pamukkale University, Denizli, Turkey; Pamukkale University Research Center for Genetic Engineering and Biotechnology, Denizli, TurkeyCorrespondence[email protected]

, Ph.D.,

Hasan Koyuncu Turkish Ministry of Health, Denizli Hemoglobinopathy Center, Denizli, Turkey

Berna Turgut Turkish Ministry of Health, Denizli Hemoglobinopathy Center, Denizli, Turkey

Ayfer Atalay Department of Biophysics, Medical Faculty, Pamukkale University, Denizli, Turkey; Pamukkale University Research Center for Genetic Engineering and Biotechnology, Denizli, Turkey

Sanem Yildiz Department of Biophysics, Medical Faculty, Pamukkale University, Denizli, Turkey; Pamukkale University Research Center for Genetic Engineering and Biotechnology, Denizli, Turkey

Anzel Bahadir Department of Biophysics, Medical Faculty, Pamukkale University, Denizli, Turkey; Pamukkale University Research Center for Genetic Engineering and Biotechnology, Denizli, Turkey

Aylin Köseler Department of Biophysics, Medical Faculty, Pamukkale University, Denizli, Turkey; Pamukkale University Research Center for Genetic Engineering and Biotechnology, Denizli, Turkey

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Abstract

Denizli Province is located in the inner part of the Aegean region of Turkey and is one of the target areas for premarital screening. Here we report the abnormal hemoglobins (Hbs) observed during a premarital screening program in our region. According to our results, Hb D-Los Angeles [β121(GH4)Glu→Gln (GAA→CAA] (also known as D-Punjab, D-North Carolina, D-Portugal, Oak Ridge and D-Chicago), is the most frequent abnormal Hb in this region.

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High Incidence of Hb D-Los Angeles [β121(GH4)Glu→Gln] in Denizli Province, Aegean Region of Turkey

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High Incidence of Hb D-Los Angeles [β121(GH4)Glu→Gln] in Denizli Province, Aegean Region of Turkey

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