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Hemoglobin
international journal for hemoglobin research
Volume 30, 2006 - Issue 2
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SHORT COMMUNICATION

Secretory Phospholipase A2 Levels in Patients with Sickle Cell Disease and Acute Chest Syndrome

, , , , , , , , , & show all
Pages 165-170 | Received 17 Apr 2005, Accepted 19 Oct 2005, Published online: 07 Jul 2009
 

Abstract

In a multicenter study (eight centers), we determined secretory phospholipase A2 (sPLA2) levels in patients with sickle cell disease and acute chest syndrome (ACS). The diagnosis of ACS was made according to established criteria. The sPLA2 levels were determined in blood samples collected at baseline (time of diagnosis) and serially thereafter up to day 22–35 follow-up visits. Thirty-four of 43 (80%) patients with ACS had enzyme levels ≥1.00 AU at baseline. The enzyme levels decreased significantly on Days 2 through Days 25–35 after baseline. Nine of 43 (20%) patients had baseline sPLA2 values of <1.00 AU with six of them never exceeding 1.00 AU at any point in time during follow-up. The data indicate that the reliability of sPLA2 for predicting the development of ACS is not perfect (100%) as was previously reported but occurs in about 80% of the patients.

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