Hb Hekinan in a Taiwanese Subject: A G→T Substitution at Codon 27 of the α1-Globin Gene Abolishes an HaeIII Site

Hung-Chang Shih Department of Laboratory Medicine, China Medical University Hospital, Taichung, Taiwan; Department of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan

Mu-Chin Shih Department of Laboratory Medicine, China Medical University Hospital, Taichung, Taiwan

Yu-Chang Chang Department of Laboratory Medicine, China Medical University Hospital, Taichung, Taiwan

Ching-Tien Peng Department of Laboratory Medicine, China Medical University Hospital, Taichung, Taiwan; Department of Biotechnology and Bioinformatics, Asia University, Taichung, Taiwan

Tien-Jye Chang Department of Veterinary Medicine, National Chung Hsing University, Taichung, TaiwanCorrespondence[email protected]

Jan-Gowth Chang Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanCorrespondence[email protected]

Abstract

We recently observed a heterozygote for Hb Hekinan in a Taiwanese subject. The molecular lesion of Hb Hekinan is a substitution of G→T at codon 27 of the α1-globin gene, which abolishes an HaeIII restriction enzyme site. Hb Hekinan [α27(B8)Glu→Asp, GAG→GAC (α2)] has not been found in Taiwan. This variant can be detected by high performance liquid chromatography (HPLC) but not by capillary or cellulose electrophoresis.

Keywords:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Hb Hekinan in a Taiwanese Subject: A G→T Substitution at Codon 27 of the α1-Globin Gene Abolishes an HaeIII Site

Information for

Open access

Opportunities

Help and information

Hb Hekinan in a Taiwanese Subject: A G→T Substitution at Codon 27 of the α1-Globin Gene Abolishes an HaeIII Site

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature