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Hemoglobin
international journal for hemoglobin research
Volume 43, 2019 - Issue 1
127
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Review Article

Purulent Pericarditis in Sickle Cell Disease Due to Streptococcus agalactiae; a Unique Case Report and Literature Review

, , ORCID Icon, , , & show all
Pages 1-3 | Received 29 Aug 2018, Accepted 26 Jan 2019, Published online: 18 Mar 2019
 

Abstract

Purulent pericarditis is a localized infection with a thick, fibrinous hypercellular exudate and is historically associated with a high mortality. We describe a case of purulent pericarditis due to Streptococcus agalactiae (S. agalactiae) in a 30-year-old woman with sickle cell disease who presented with fever, dyspnea, and S. agalactiae septicemia. Despite timely initiation of antibiotics, she developed a large purulent pericardial effusion requiring surgical pericardiocentesis followed by a pericardial window. At 14 months follow-up, she has remained asymptomatic without sequelae. A review of the literature contained only four patients with purulent pericarditis in sickle cell patients. We discuss the unique aspects of this case in the context of purulent pericarditis in the age of modern antibiotics and hypothesize on the pathogenesis of delayed pericardial effusion after pericarditis.

Disclosure statement

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

Figure 1. Chest CT without contrast Day 3: bilateral lower lung airspace disease. Additionally, there are peripheral linear/wedge-shaped opacities within the right upper and lower, as well as the left lower lobes.

Figure 1. Chest CT without contrast Day 3: bilateral lower lung airspace disease. Additionally, there are peripheral linear/wedge-shaped opacities within the right upper and lower, as well as the left lower lobes.

Figure 2. Chest CT with contrast Day 14: large pericardial effusion with pericardial thickening and hyper-enhancement. Bilateral pleural effusions with adjacent lower lobe atelectasis.

Figure 2. Chest CT with contrast Day 14: large pericardial effusion with pericardial thickening and hyper-enhancement. Bilateral pleural effusions with adjacent lower lobe atelectasis.

Figure 3. Trans-thoracic echocardiogram (ECHO) on Day 14: pericardial effusion.

Figure 3. Trans-thoracic echocardiogram (ECHO) on Day 14: pericardial effusion.

Additional information

Funding

This study was funded by the State University of New York, Downstate Medical Center, Brooklyn, NY, USA.

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