Unstable Hemoglobin Variants: The Need for Clinical Vigilance in Infants with Congenital Jaundice

Abstract

Unstable hemoglobin (Hb) variants are a rare etiology of congenital jaundice caused by hemolytic anemia. For infant patients with jaundice this disorder is often under diagnosed or the last consideration. We report a 14-month-old boy, who presented with a long-standing jaundice. His diagnosis of Hb Sabine [β91(F7)Leu→Pro; HBB: c.275T > C] was not revealed until gene sequencing of the β-globin gene was performed.

Keywords:

• Hemoglobinopathies
• Hb Sabine
• hemolytic anemia
• neonatal jaundice
• unstable hemoglobin (Hb)

Disclosure statement

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

Additional information

Funding

This study was supported by the National Natural Science Foundation of China [81571448].