Abstract
Venous thromboembolism (VTE) in individuals with sickle cell disease is common and portends a poor prognosis. The role of leukocyte count and its subsets on risk of VTE in sickle cell disease are not known. We conducted a retrospective case-control study and analyzed for leukocyte count at the time of VTE and 3 months prior. Leukocyte and neutrophil counts were elevated at the time of VTE (p = 0.003 and p = 0.0006, respectively) and 3 months prior (p = 0.001 and p = 0.0096, respectively) when compared to controls. Baseline leukocytosis and neutrophilia may be associated with subsequent risk for thrombosis in sickle cell disease.
Acknowledgment
Shashank Sarvepalli is supported by a National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Institutional National Service Award (T32) from the National Institutes of Health under Award Number T32 DK083266.
Disclosure statement
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.
Correction Statement
This article has been republished with minor changes. These changes do not impact the academic content of the article.