Fetal Hemoglobin H Hydrops Fetalis: Another Three Case Reports

Abstract

We report three cases of fetalis hydrops associated with nondeletional α-thalassemia. Two cases were caused by hemoglobin (Hb) H-Quong Sz disease, and one caused by homozygous Hb Constant Spring. Fetal hydrops occurred in the late second trimester in all three cases. Our study indicates that for pregnancies at risk for fetal nondeletional Hb H disease, strict ultrasound follow-up is particularly important. Even without techniques of intrauterine transfusion treatment, early prenatal diagnosis can enable parents to make timely decisions.

Keywords:

• α-thalassemia (α-thal)
• Hb Quong Sze
• Hb Constant Spring
• hydrops fetalis

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The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

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