Interconversion Kinetic Studies of Betamethasone Acetate Polymorphs in Water

ABSTRACT

This study assessed the effect of polymers on the transformation of polymorphs of betamethasone acetate (BA) when suspended in water. The results showed that the polymers, in particular HPMC E5, retarded the transition of the forms Iα and Iβ. However, the form Iα, as the metastable form, with the aid of HPMC E5, was preferred for BA suspension preparation through kinetic studies, while the form Iβ was not suitable due to its instability in water.

KEYWORDS:

• Betamethasone acetate
• Polymorph
• Kinetic study
• Polymer
• Metastable form
• Transformation retardation