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Research Article

Using an Experimental Design to Identify and Quantify the Effects of Environment Related Test Parameters on the In Vitro Mucoadhesivity Testing of a Propanolol Buccal Tablet

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Pages 709-716 | Published online: 26 Sep 2008
 

ABSTRACT

This study sought to identify and quantify the effects of environmental test parameters on the mucoadhesivity of a propranolol tablet. Their effects on Maximum Detachment Force (MDF) measurements were evaluated using a Box-Behnken design matrix. Prehydration time (PT) had a statistically significant negative main effect while contact force (CF) had no significant effect on in vitro MDF measurements. While contact time (CT) had no significant main or quadratic effects, it had a positive interaction effect with PT. The mathematical model was statistically validated and a PT of 3.5 min and a CT of 5 min was proposed for mucoadhesion testing by the tensile method during formulation optimization.

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