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Original Article

In vivo–in vitro correlation for amoxicillin trihydrate 1000 mg dispersible tablet

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Pages 981-985 | Received 04 Jul 2008, Accepted 09 Jan 2009, Published online: 19 May 2009
 

Abstract

Objectives: An in vivo–in vitro correlation (IVIVC) for amoxicillin dispersible tablet was established. Methods: The model of absorption was constructed with type 2 dissolution apparatus and with the use of variable hydrodynamic conditions simulating passage through upper part of gastrointestinal tract. The in vivo test was performed on 24 volunteers. Summary of results: The predicted errors for AUC and Cmax were calculated. Conditions of the in vitro test were discriminative to capsules, which were claimed to have lower bioavailability. The zero-order process of amoxicillin absorption enabled to establish the IVIVC more easily. Overall conclusions: The described model showed features of level A correlation for immediate release dosage form and the zero-order process of amoxicillin absorption is an advantage for establishing IVIVC.

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