Abstract
The anticancer activity and pharmacokinetic properties of encapsulated polyherbal nanoparticles (gallic acid (GA) and quercetin nanocomposite) and polyherbal extract (amla and pomegranate fruit peels) in normal and DMH-induced colorectal cancer in rats were examined in this work. In normal and DMH-induced rats, a pharmacokinetic study demonstrated that polyherbal nanoparticles had a typical sustained release profile with a fourfold increase in bioavailability when compared to polyherbal extract. Based on serum–concentration profiles of polyherbal nanoparticles and polyherbal extract following oral administration, the pharmacokinetic parameters for polyherbal nanoparticles and polyherbal extract were established using a single compartmental approach. This research suggests that encapsulating GA and quercetin in polymeric nanoparticles improves their oral bioavailability and anti-colon cancer efficacy. Polymeric nanoparticles could be a novel therapeutic possibility for carcinogenesis prevention.
Acknowledgements
The author(s) express their deep sense of gratitude towards Bharati Vidyapeeth College of Pharmacy (Kolhapur, Maharashtra) and Government College of Pharmacy (Karad, Maharashtra) for provision of obligatory facilities to carry out present research work. Author(s) are profusely thankful to Dr. Riyaz Ali M. Osmani, Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, for his valuable inputs and constructive suggestions.
Ethics approval and consent to participate: For this study, prior clearance from an institutional animal ethics committee (approval number BVCPK/CPCSEA/IAEC/17/19) was obtained and the experimental procedure followed CPCSEA guidelines.
Consent for publication: The authors have read the final version and give their consents for the article to be published in Drug Delivery and Translational Research.
Author contributions
Ms. P. S. Patil: conceived and designed the experiments; contributed reagents, materials, analysis tools or data; performed the experiments; analyzed and wrote the paper. Dr. S. G. Killedar: conceived and designed the experiments; analyzed and interpreted the data; wrote the paper.
Disclosure statement
The authors declare that they have no conflict of interest.
Data availability statement
Data included in article/supplementary material/referenced in article.