Effect of mango butter on the physicochemical properties of beeswax-Moringa seed oil-based oleogels for topical application

Abstract

Objective

The purpose of this research was to determine any connections between the characteristics of oleogels made of beeswax and the impact of mango butter.

Methods

Oleogel was prepared through inverted tube methods, and optimized through oil binding capacity. Other evaluations like bright field and polarized microscopy, Fourier-transform infrared (FTIR) spectroscopy, crystallization kinetics, mechanical study, and X-ray diffractometry (XRD). The drug release kinetic studies and in vitro antibacterial studies were performed.

Results

FTIR study reveals that the gelation process does not significantly alter the chemical composition of the individual components. Prepared gel exhibiting fluid-like behavior or composed of brittle networks is particularly vulnerable to disruptions in their network design. The incorporation of mango butter increases the drug permeation. In-vitro microbial efficacy study was found to be excellent.

Conclusion

The studies revealed that mango butter can be used to modify the physico-chemical properties of the oleogels.

Keywords:

• Mango butter
• Moringa seed oil
• beeswax oleogel
• linezolid
• topical infections
• antimicrobial efficacy

Acknowledgement

We are thankful to Prof. Kunal Pal, HOD, Department of Biotechnology and Medical Engineering, NIT, Rourkela, for providing laboratory and equipment facilities. The research work received no internal or external funding.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

Data is available on request from the authors.

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.