Backstepping Model Predictive Controller for Blood Glucose Regulation in Type-I Diabetes Patient

Abstract

A robust method for optimal insulin injection as an accurate remedial measure has been focused to design since early three decades. This paper presents a novel approach to regulate the blood glucose (BG) based on backstepping model predictive controller (BMPC) for type-I diabetes mellitus (TIDM) patients. To implement the proposed approach BMPC, initially a linearized state-space model is derived from the non-linear TIDM patient with micro-insulin dispenser (MID). Through necessary simulation in MATLAB/SIMULINK platform, the proposed approach is verified and the results are presented to demonstrate its accuracy, stability, and robustness. The comparative results are presented with other suggested methods by various researchers in recent times. The results obtained under various physiological conditions with regards to meal, exercise, and uncertainties due to noise reveal the enhanced performance of the approach to control the BG level within the range of normoglycaemia (70–120 mg/dl).

KEYWORDS:

• Artificial pancreas
• Backstepping control
• Blood glucose level
• Micro-insulin dispenser
• Model predictive control
• Type-I diabetes

Additional information

Notes on contributors

Akshaya Kumar Patra

Akshaya Kumar Patra is presently working as an Assistant Professor in the Department of EEE, ITER, S’O’A University, Bhubaneswar, Odisha, India. He received his BE degree from O.E.C, Utkal University, Odisha, India, in 1997, the ME degree from Bengal Engineering and Science University, Shibpur, Howrah, India, in 2006, and PhD degree in biomedical engineering from Siksha “O” Anusandhan University, Bhubaneswar, Odisha, India, in 2018. His main research includes control systems, robust control, and biomedical engineering. Corresponding author. Email: [email protected]; [email protected]

Alok Kumar Mishra

Alok Kumar Mishra is presently working as an Assistant Professor in the Department of EEE, ITER, S’O’A University, Bhubaneswar, Odisha, India. He received his BE degree from O.E.C, Utkal University, Odisha, India, in 2002, and the MTech degree from IIT Roorkee, India, in 2011. His main research includes control systems, robust control, and biomedical engineering.Email: [email protected]

Pravat Kumar Rout

Pravat Kumar Rout is a Professor at the Department of EEE, ITER, S’O’A University, Bhubaneswar, India. He received his ME degree in power system engineering from Thiagarajar College of Engineering, Madurai, Tamil Nadu, and PhD degree in power system engineering from Biju Pattanaik University of Technology, India, in 1995 and 2010, respectively. His main research area focuses on soft computing, power system operation and control, biomedical engineering.Email: [email protected]