Fabrication of Stress and Temperature Measurement Sensors and Possible Integration with Fabricated Biodegradable Drug Delivery Device

ABSTRACT

This paper presents the design and fabrication of flexible skin conductance and temperature sensor using PDMS with a minimized skin contact area and increased device flexibility. The design and fabrication of reservoir-based (RB) drug delivery system (DDS) using microfabrication technology is also presented in this paper with possible future integration with these sensors. While the sensors can be used for the measurement of galvanic skin response for detecting emotional activity and monitoring of human stress in daily life, the RB-DDS can be used for delivering drug like insulin in a controlled and sustained manner to the target site. The sensor performance has been experimentally verified using the BITalino (r)evolution Board Kit while the DDS has been tested in-vivo and in-vitro. A comparative study on the sticking property of PDMS with aluminium was also conducted by exposing PDMS with oxygen and argon plasma.

KEYWORDS:

• Argon plasma
• Drug delivery
• Eletrodermal activity measurment (EDA)
• Emotional activity
• Galvanic skin response
• Oxygen plasma
• PDMS
• Skin conductivity

Acknowledgements

A preliminary version of this work was published in ICM 2017 conference [20].

Additional information

Notes on contributors

Joyline D’sa

Joyline Dsa is a research scholar in the department of Electronics and Communication Engineering, at Indian Institute of Technology Allahabad, India. She has completed her MTech from IIIT-Allahabad. Having 7 years of experience in the field of microelectronics, she is currently working on the research areas of fabrication of drug delivery devices for controlled applications, nanotechnology, Bio-MEMS High K dielectrics, micro electro mechanical systems, (MEMS), VLSI technology.

Divyesh Sachan

Divyesh Sachan is a research scholar at Indian Institute of Technology Allahabad, India. He has completed his MTech from Delhi Technological University Delhi. Currently works at the Microelectronics Division, Department of Electronics and Communication Engineering, Indian Institute of Information Technology Allahabad. His research interests are mixed signal design, RF and analog VLSI design. Email: [email protected]

Manish Goswami

Manish Goswami has completed his PhD, from Birla Institute of Technology Mesra, Ranchi, India, in the year 2012. He is currently working as associate & Head of the Department of Electronics and Communication Engineering at Indian Institute of Information Technology Allahabad. Having about 15 years of experience in the research and academic field, his area of expertise are analog and digital VLSI design, MEMS. Email: [email protected]