ICPMS based multiplexed bioassay: Principles, approaches and progresses

Abstract

Recent developments in multiplex bioassay around the theme of precision diagnostics have gained great focus. Inductively coupled plasma mass spectrometry (ICPMS) is emerging as a powerful platform for multiplex bioassay due to its high sensitivity, wide dynamic range, particularly its reliable multiplex sensing ability. This review discusses the progress being made in the multiplex bioassay applicating ICPMS, mainly emphasizes on varieties of biomarkers and methodological innovations. Also, we summarized limitations and proposed prospects to shed new light on the emergence of more powerful and application-oriented analytical methods.

Keywords:

• ICPMS
• multiplex assay
• element tagging
• biomarkers
• bioassay

Acknowledgments

We gratefully acknowledged the National Natural Science Foundation of China (No. 22074098 & 22074096), the Talents Program of Sichuan Province (No. 903), Sichuan Science and Technology Program (19YYJC2423), and the Fundamental Research Funds for the Central Universities.

Disclosure statement

No potential conflict of interest was reported by the authors.