3
Views
0
CrossRef citations to date
0
Altmetric
Original Articles

Increase in Penvascular Noradrenergic Nerve Density and Decrease in Acetylcholinesterase-Positive Sympathetic Nerve Density in the Kidneys of Spontaneously Hypertensive Rats

&
Pages 1031-1049 | Published online: 23 May 2017
 

ABSTRACT

The density and pattern of sympathetic nerve fibres in the kidneys of 16-week-old spontaneously hypertensive rats (SHR) and of control age-matched normotensive Wistar-Kyoto (WKY) rats were studied by catecholamine histofluorescence and acetylcholinesterase histochemical techniques.

Varicose noradrenergic fibres primarily supply renal vasculature and were concentrated in small arteries and in afferent glomerular arterioles. The number and the density of these nerve fibres were increased in SHR. Acetylcholinesterase-positive nerve fibres were distributed to the renal vascular tree in the same way as the noradrenergic nerves and disappeared after chemical sympathectomy, suggesting their sympathetic nature. Acetylcholinesterase-positive perivascular nerve fibres were decreased in SHR.

The possible significance of the two directional behaviour of sympathetic nerves (noradrenergic and acetylcholinesterase-positive) in the kidneys of SHR is discussed.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.