Evidence for a Predominant Renal Secretion and Clearance of Inactive Plasma Renin, Studied by In Vivo Inhibition of Protein Synthesis, and Inhibition of Renal Tubular Protein Reabsorption

A.H. NielsenInstitute of Biochemistry The Royal Dental College and The Medical School Nøirre Alle 20, DK-2200 Copenhagen N Denmark

K.L. HermannInstitute of Biochemistry The Royal Dental College and The Medical School Nøirre Alle 20, DK-2200 Copenhagen N Denmark

I. MazantiInstitute of Biochemistry The Royal Dental College and The Medical School Nøirre Alle 20, DK-2200 Copenhagen N Denmark

K. PoulsenInstitute of Biochemistry The Royal Dental College and The Medical School Nøirre Alle 20, DK-2200 Copenhagen N Denmark

ABSTRACT

Inactive plasma renin is mainly secreted and eliminated by the kidneys in the mouse. The half-life of inactive plasma renin is 6 hours or less. The kidneys remove inactive renin from the circulation by glomerular ultrafiltration.

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Evidence for a Predominant Renal Secretion and Clearance of Inactive Plasma Renin, Studied by In Vivo Inhibition of Protein Synthesis, and Inhibition of Renal Tubular Protein Reabsorption

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Evidence for a Predominant Renal Secretion and Clearance of Inactive Plasma Renin, Studied by In Vivo Inhibition of Protein Synthesis, and Inhibition of Renal Tubular Protein Reabsorption

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