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Articles

Influence of the C677T Polymorphism of the MTHFR Gene on Oxidative Stress in Women With Overweight or Obesity: Response to a Dietary Folate Intervention

, MD, , PhD, , MD, , MD, , PhD ORCID Icon, , MD, , MD, , PhD ORCID Icon, , PhD ORCID Icon, , PhD ORCID Icon, , PhD, , PhD, , PhD, , PhD, , PhD, , PhD & , PhD ORCID Icon show all
Pages 677-684 | Received 14 Jul 2017, Accepted 27 Mar 2018, Published online: 27 Apr 2018
 

ABSTRACT

The C677T polymorphism of the methylenetetrahydrofolate reductase gene (MTHFR) is related to folate metabolism and can alter the levels of biochemical markers.

Objective: Investigate the influence of the MTHFR C677T polymorphism on the effects of a dietary folate intervention on oxidative stress in women with overweight or obesity.

Methods: Forty-eight adult women with overweight or obesity were subjected to a 24-hour dietary recall, anthropometric measurements, biochemical analysis, and genotyping of the MTHFR C677T polymorphism. They were allocated by convenience sampling to 2 groups, which received 300 g of folate-rich vegetables containing 191 µg/d (Group 1) (n = 24) or 95 µg/d (Group 2) (n = 24) of folate for 8 weeks.

Results: The dietary intervention increased the serum folic acid levels in the 2 analyzed groups. The intervention with 191 µg/d of folate led to relevant results in terms of homocysteine levels (p = 0.0005) and total antioxidant capacity (p = 0.0261); the effect was larger among carriers of the TT genotype.

Conclusions: The study demonstrated the beneficial effect of folate intake in terms of a TAC elevation for the CC and TT genotypes of the MTHFR C677T polymorphism, an increase in folic acid levels for all genotypes, and a reduction in the Hcy levels for the TT genotype in response to an intervention consisting of an intake of 191 µg/d of folate supplied by vegetables.

Acknowledgments

We thank the project coordinator, Dr. Maria José de Carvalho Costa, and the funding agencies that enabled the project (National Council of Scientific and Technological Development [Conselho Nacional de Pesquisas–CNPq], Ministry of Health and Paraíba Research Support Foundation [Fundação de Apoio à Pesquisa do Estado da Paraíba–FAPESQ, PB]), and our research collaborators (Graduate Program in Nutrition Sciences, Federal University of Paraíba).

Additional information

Funding

This work was supported by the Paraíba Research Support Foundation (Fundação de Apoio à Pesquisa do Estado da Paraíba - FAPESQ, PB - EFP_00008187).

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