ABSTRACT
Four positional isomers of 61,6n-di-O-(D-galactopyranosyl)cyclomaltooctaoses (cG8s, γ-cyclodextrins) (n = 2−5) were chemically synthesized using the trichloroacetimidate method. The desired compounds having two α-(1→6)-linkages were isolated from a mixture of configurational isomers by HPLC, and their structures were confirmed by 13C NMR spectroscopy and FAB-high resolution mass spectra (HRMS). The elution behavior of their four positional isomers on an ODS column by HPLC is discussed.