Carbohydrate-Based Peptido Mimetics. Synthesis of Two New Scaffolds for Combinatorial Libraries.

Abstract

The recent utilisation of the glucopyranose ring as scaffold for the synthesis of a potent somatostatin agonist demonstrated the use of monosaccharides as viable templates in drug design.^2,3 Monosaccharide-based mimics provide enantiomerically pure, rigid moieties (able to give precise orientation of functional groups), with a high degree of oxygenation to assure water solubility.⁴ Moreover, carbohydrates exhibit a high combinatorial density. These advantages prompted us to synthesise new monosaccharide derivatives as carbohydrate scaffolds for potential drug design.