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Abstract
The synthesis of methyl 3,5‐di‐O‐benzoyl‐2‐deoxy‐2‐fluoro‐2‐C‐methyl‐β‐D‐ribofuranoside and the conversion to the corresponding 1‐O‐acetyl‐3,5‐di‐O‐benzoyl‐2‐deoxy‐2‐fluoro‐2‐C‐methyl‐D‐ribofuranose and 1,3,5‐tri‐O‐benzoyl‐2‐deoxy‐2‐fluoro‐2‐C‐methyl‐D‐ribofuranose is reported. The key synthetic step is the fluorination of the tertiary center of methyl 3,5‐di‐O‐benzyl‐2‐C‐methyl‐β‐D‐arabinofuranoside to provide methyl 3,5‐di‐O‐benzyl‐2‐deoxy‐2‐fluoro‐2‐C‐methyl‐β‐D‐ribofuranoside.
Acknowledgement
Dr. R. F. Schinazi is the principal founder and former consultant of Pharmasset Inc. His laboratory received no funding for this work. This paper is dedicated to the loving memory of our friend and colleague Dr. J. Christian Mason.