A New Method for Selective Deprotection of Anomeric N,O-Dimethylhydroxylamine Promoted by TMSCl

Shengjun Huang Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, 200433, People's Republic of China

Jun Liao Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, 200433, People's Republic of China

Qingjie Zhao Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, 200433, People's Republic of China

Xiaoyun Chai Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, 200433, People's Republic of China

Baogang Wang Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, 200433, People's Republic of China

Shichong Yu Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, 200433, People's Republic of China

Qiuye Wu Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, 200433, People's Republic of China

show all

Abstract

TMSCl was shown to be an efficient reagent for selective deprotection of the anomeric position protected as N,O-dimethylhydroxylamine glycoside. This deprotection condition was proved to be compatible with a number of protecting groups, such as the TBDPS, acetyl, benzyl, benzylidene, and benzoyl groups.

Keywords:

ACKNOWLEDGMENTS

This work was supported by the Major Project of the Science and Technology Ministry of China (No.2012ZX09502001-005).

Shengjun Huang and Jun Liao contributed equally to this work.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

A New Method for Selective Deprotection of Anomeric N,O-Dimethylhydroxylamine Promoted by TMSCl

Information for

Open access

Opportunities

Help and information

A New Method for Selective Deprotection of Anomeric N,O-Dimethylhydroxylamine Promoted by TMSCl

Abstract

ACKNOWLEDGMENTS

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature