The Microbial Pathology of Neu5Ac and Gal Epitopes

Muhammad Ramzan Manwar Hussain Princess Al-Jawhara Al-Brahim Center of Excellence in Research of Hereditary Diseases, Department of Genetic Medicine, School of Medicine, King Abdulaziz University, Saudi Arabia

Hani Asfour Princess Al-Jawhara Al-Brahim Center of Excellence in Research of Hereditary Diseases, Department of Genetic Medicine, School of Medicine, King Abdulaziz University, Saudi Arabia; Department of Medical Microbiology and Parasitology, School of Medicine, King Abdulaziz University, Saudi Arabia

Muhammad Yasir King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia

Asifullah Khan Department of Biochemistry, UCS Shankar Campus, Abdul Wali Khan University, Mardan, Pakistan

Hussein Sheikh Ali Mohamoud Princess Al-Jawhara Al-Brahim Center of Excellence in Research of Hereditary Diseases, Department of Genetic Medicine, School of Medicine, King Abdulaziz University, Saudi Arabia

Jumana Y. Al-Aama Princess Al-Jawhara Al-Brahim Center of Excellence in Research of Hereditary Diseases, Department of Genetic Medicine, School of Medicine, King Abdulaziz University, Saudi Arabia

Abstract

Glycans play a vital role in modulating many physiological and pathological phenomena of microbes and humans, such as bacterial adhesion, colonization, host-microbial interactions, cancer recognition, and blood group determination. The aim of the current review is to provide an account of the functions of N-acetyl sialic acid (Neu5Ac) and galactose (Gal) residues in microbial pathology. Specifically, an overview of the biosynthesis and metabolism of Neu5Ac and Gal residues in different bacterial species will provide a better understanding of microbial pathogenesis in the human body.

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ACKNOWLEDGMENT

We are thankful to the editors for their critical review and fruitful suggestions for this article.

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The Microbial Pathology of Neu5Ac and Gal Epitopes

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The Microbial Pathology of Neu5Ac and Gal Epitopes

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