Structure of the Type VI Group B Streptococcus Capsular Polysaccharide Determined by High Resolution NMR Spectroscopy

Grigorij Kogan Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario, K1A OR6, Canada

Dušan Uhrín Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario, K1A OR6, Canada

Jean-Robert Brisson Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario, K1A OR6, Canada

Lawrence C. Paoletti Channing Laboratory, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA

Dennis L. Kasper Channing Laboratory, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA; Beth Israel Hospital, Harvard Medical School, Boston, Massachusetts, 02115, USA

Christina von Hunolstein Laboratory of Bacteriology and Medical Mycology, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy

Graziella Orefici Laboratory of Bacteriology and Medical Mycology, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy

Harold J. Jennings Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario, K1A OR6, Canada

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Abstract

The structure of the capsular polysaccharide of the recently characterized type VI Group B Streptococcus (GBS) has been established using one- and two-dimensional homo- and heterocorrelated ¹H and ¹³C NMR spectroscopy. The native polysaccharide contains D-glucose, D-galactose and sialic acid in the molar ratio 2:2:1. The structure of its repeating unit is:

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Structure of the Type VI Group B Streptococcus Capsular Polysaccharide Determined by High Resolution NMR Spectroscopy

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Structure of the Type VI Group B Streptococcus Capsular Polysaccharide Determined by High Resolution NMR Spectroscopy

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