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Original Articles

An Approach to A 1-Oxacephem Skeleton from D-Galactose

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Pages 1103-1114 | Received 29 Mar 1994, Accepted 19 Jul 1994, Published online: 24 Sep 2006
 

Abstract

2,4,6-Tri-O-benzyl-D-galactal (1) was transformed into a 1-oxacephem skeleton. The sequence of reaction involved: [2+2]cycloaddition, N-alkylation, glycolic cleavage of the vic-diol grouping, reduction of dialdehyde and cyclization to the title skeleton.

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