Mollification of Cytotoxicity of Sulfated Polysaccharides by Fibroblast Growth Factors¹

Megumi Kunou Department of Biomolecular Engineering, Tokyo Institute of Technology, Nagatsuta, Midori-ku, Yokohama, 227, Japan

Takashi Ohtsuki Department of Biomolecular Engineering, Tokyo Institute of Technology, Nagatsuta, Midori-ku, Yokohama, 227, Japan

Toshihiro Akaike Department of Biomolecular Engineering, Tokyo Institute of Technology, Nagatsuta, Midori-ku, Yokohama, 227, Japan

Kenichi Hatanaka Department of Biomolecular Engineering, Tokyo Institute of Technology, Nagatsuta, Midori-ku, Yokohama, 227, Japan

Abstract

Sulfated polysaccharide which had a relatively high degree of sulfation showed cytotoxicity to 3T3-L1 fibroblasts. Acidic and basic fibroblast growth factors inhibited the cell damage caused by the sulfated polysaccharides, while epidermal growth factor and platelet growth factor had no effects.

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Mollification of Cytotoxicity of Sulfated Polysaccharides by Fibroblast Growth Factors¹

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Mollification of Cytotoxicity of Sulfated Polysaccharides by Fibroblast Growth Factors1

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Mollification of Cytotoxicity of Sulfated Polysaccharides by Fibroblast Growth Factors¹