Structure of 2′,3′-0-Isopropylidene-5-Bromouridine

Abstract

The crystal and molecular structure of the title compound has been determined by the X-ray diffraction method. The crystals are orthorhombic, space group P2₁2₁2₁ (Z=4), with the unit cell dimensions a=5.244(2), b=14.916(6) and c=19.068(5) A. The structure was solved by direct methods and refined up to the R value of 0.058 by the full matrix least-squares method. The glycosidic torsion angle is 13.5(11)° (anti conformation), the sugar puckering being C(3′)-exo, C(4′)-endo. The orientation of the C(5′)-0(5′) bond is gauche-gauche.