Synthesis and Some Biological Properties of Carbon-Bridged Cyclonucleosides and Their Phosphates

Abstract

Methods for the synthesis of carbon-bridged 6,5′-, 6,6′-, 6,3′-, and 6,2′-cyclopyrimidine and 8,2′-cycloadenine nucleosides and some of their phosphates are described. The 6,5′- and 6,6′-cyclouridine 2′,3′-cyclic phosphates were the substrates and their 3′-phosphates were strong inhibitors of pancreatic ribonuclease.