The Protection of The 2′-Hydroxyl Function in Oligoribonucleotide Synthesis

Abstract

A new, easily accessible and achiral 2′-ketal protective group has been designed for the use in the chemical synthesis of oligoribonucleotides; the proposed 2′-ketal group⁽¹⁾ has the additional advantage that it could be easily functionalized to the diamide (6) with aq. ammonia at the penultimate step of deblocking of oligoribonucleotides which makes it more acid-labile than the parent 2′-ketal group during the final acid-promoted deprotection step.