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Original Articles

A Simple and Stable Silica Gel Support for the Oligodeoxyribonucleotide Synthesis

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Pages 325-330 | Received 06 May 1985, Published online: 13 Dec 2006
 

Abstract

A simple and efficient synthesis of a solid support with a long chain polyamide spacer has been developed. The spacer was made by successive addition of ethylene-diamine and succinic anhydride. The obtained solid support gives very homogeneous 20 mer oligodeoxyribonucleotides, detected by HPLC and electrophoresis.

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