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Nucleosides and Nucleotides Volume 8, 1989 - Issue 2
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Original Articles

Studies on the Alkylation of Derivatives of Guanines

Jonas Kjellberg Departments of Organic Chemistry, Royal Institute of Technology, S-100 44, Stockholm, Sweden
&
Nils Gunnar Johansson Departments of Antiviral Therapy, Astra Alab AB, S-151 85, Södertälje, Sweden
Pages 225-256 | Received 24 Sep 1986, Published online: 24 Oct 2006
 
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Abstract

The synthesis of some N7- and N9-substituted guanine analogs was investigated. The influence of the base, the alkylating agent and of the type of derivatization of the purine moiety on the relative formation of the N7 and N9 isomers was studied.

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