The Inhibition of Adenosine Kinase by α,ω-Di (Adenosin - N⁶- YL) Alkanes¹

M. Prescott Departments of Biochemistry and Department of Organic Chemistry, Robert Robinson Laboratories, University of Liverpool, P.O. Box 147, Liverpool, L69 3BX, U.K.

A. G. McLennan Departments of Biochemistry and Department of Organic Chemistry, Robert Robinson Laboratories, University of Liverpool, P.O. Box 147, Liverpool, L69 3BX, U.K.

D. C. Agathocleous Departments of Biochemistry and Department of Organic Chemistry, Robert Robinson Laboratories, University of Liverpool, P.O. Box 147, Liverpool, L69 3BX, U.K.

P. C. Bulman Page Departments of Biochemistry and Department of Organic Chemistry, Robert Robinson Laboratories, University of Liverpool, P.O. Box 147, Liverpool, L69 3BX, U.K.

R. Cosstick Departments of Biochemistry and Department of Organic Chemistry, Robert Robinson Laboratories, University of Liverpool, P.O. Box 147, Liverpool, L69 3BX, U.K.

I. J. Galpin Departments of Biochemistry and Department of Organic Chemistry, Robert Robinson Laboratories, University of Liverpool, P.O. Box 147, Liverpool, L69 3BX, U.K.

Abstract

Members of a series of α,ω-di(adenosin- N ⁶-yl)alkanes, comprising two adenosine residues linked with alkyl bridges from 1 to 14 methylene units in length, were found to be inhibitors of rat liver and BHK cell adenosine kinase. The inhibition was competitive with respect to adenosine and non-competitive with respect to ATP. The corresponding α,ω-di(cytidin-N ⁴-yl) alkanes were not inhibitors and N ⁶-alkyladenosines inhibited only weakly.

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The Inhibition of Adenosine Kinase by α,ω-Di (Adenosin - N⁶- YL) Alkanes¹

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The Inhibition of Adenosine Kinase by α,ω-Di (Adenosin - N⁶- YL) Alkanes¹