Use of the 2-(4-Pyridyl)Ethyl Protecting Group in the Synthesis of DNA Fragments Via Phosphoramidite Intermediates

Shoji Hamamoto Laboratory of Bioorganic Chemistry, Department of Industrial Chemistry, Chiba Institute of Technology, Tsudanuma, Narashino, Chiba, 275, Japan

Yoshiharu Shishido Laboratory of Bioorganic Chemistry, Department of Industrial Chemistry, Chiba Institute of Technology, Tsudanuma, Narashino, Chiba, 275, Japan

Mitunori Furuta Laboratory of Bioorganic Chemistry, Department of Industrial Chemistry, Chiba Institute of Technology, Tsudanuma, Narashino, Chiba, 275, Japan

Hiroshi Takaku Laboratory of Bioorganic Chemistry, Department of Industrial Chemistry, Chiba Institute of Technology, Tsudanuma, Narashino, Chiba, 275, Japan

Masahiko Kawashima Research & Development Division, Miyoshi Oil Co., Ltd., Horikiri, Katsushika, Tokyo, 124, Japan

Makoto Takaki Research & Development Division, Miyoshi Oil Co., Ltd., Horikiri, Katsushika, Tokyo, 124, Japan

Abstract

2-(4-Pyridyl)ethyl is a new protecting group for the internucleotidic bonds in the synthesis of deoxyribooligonucleotides by the phosphoramidite approach. This group is stable to alkali and acid conditions, and can be removed easily by two step procedures under mild conditions. The synthesis of deoxyribo-oligonucleotides by using phosphoramidite units containing 2-(4-pyridyl)ethyl group is also described.

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Use of the 2-(4-Pyridyl)Ethyl Protecting Group in the Synthesis of DNA Fragments Via Phosphoramidite Intermediates

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Use of the 2-(4-Pyridyl)Ethyl Protecting Group in the Synthesis of DNA Fragments Via Phosphoramidite Intermediates

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