Investigation of the Synthesis of 2-Carbamoylmethyl-6-D-Ribofuranosylpyridine

E. De Vos University of Antwerp (R.U.C.A.), Laboratory for Organic Chemistry, Groenenborgerlaan 171, B-2020, Antwerp, Belgium

E. L. Esmans University of Antwerp (R.U.C.A.), Laboratory for Organic Chemistry, Groenenborgerlaan 171, B-2020, Antwerp, Belgium

F. C. Alderweireldt University of Antwerp (R.U.C.A.), Laboratory for Organic Chemistry, Groenenborgerlaan 171, B-2020, Antwerp, Belgium

J. A. Lepoivre University of Antwerp (R.U.C.A.), Laboratory for Organic Chemistry, Groenenborgerlaan 171, B-2020, Antwerp, Belgium

Abstract

During the course of our study on the synthesis of new pyridine-C-nucleosides with potential anti-viral and/or anti-tumourai properties, the preparation of 2-carbamoylmethyl-6-β-D-ribofuranosylpyridine 1, by means of a lithiation reaction on 2-(2,3-0-isopropylidene-β D-nbofuranosyl)-6-methylpyridine 2, was investigated (Scheme I). The latter compound was prepared by treating 6-methyl- toluenesulphonic acid. 2-(& D-ribofuranosyl)pyridine 1 2 with 2.2-dimethoxypropane in the presence of p-

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Investigation of the Synthesis of 2-Carbamoylmethyl-6-D-Ribofuranosylpyridine

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Investigation of the Synthesis of 2-Carbamoylmethyl-6-D-Ribofuranosylpyridine

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