Low Level, Detection of Modified DNA Bases and Nucleosides by FAB MS/MS

E. De Pauw Commission of the European Comrrunities, Joint Research Centre, Radiochemistry Division, Environment Institute, 21020, ISPRA (VA), Italy

E. Marafante Commission of the European Comrrunities, Joint Research Centre, Radiochemistry Division, Environment Institute, 21020, ISPRA (VA), Italy

J. Riego Commission of the European Comrrunities, Joint Research Centre, Radiochemistry Division, Environment Institute, 21020, ISPRA (VA), Italy

C. Leuratti Commission of the European Comrrunities, Joint Research Centre, Radiochemistry Division, Environment Institute, 21020, ISPRA (VA), Italy

Abstract

The identification and quantitation of DNA adducts formed by reaction of genotoxic chemicals with DNA may provide direct evidence of exposure t o mutagens and carcinogens and may make possible a beginning of risk estimation based on Molecular Dosimetry approach.

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Low Level, Detection of Modified DNA Bases and Nucleosides by FAB MS/MS

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Low Level, Detection of Modified DNA Bases and Nucleosides by FAB MS/MS

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