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Nucleosides and Nucleotides Volume 9, 1990 - Issue 3
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HPLC and Synthesis Strategy in Nucleoside and (Oligo)Nucleotide Chemistry

A. Pompon Laboratoire de Chimie Bio-organique, case 008, UA 488 du CNRS Université des Sciences et Techniques du Languedoc Place E. Bataillon, 34060, Montpellier-Cedex 1, France
,
F. Puech Laboratoire de Chimie Bio-organique, case 008, UA 488 du CNRS Université des Sciences et Techniques du Languedoc Place E. Bataillon, 34060, Montpellier-Cedex 1, France
,
G. Gosselin Laboratoire de Chimie Bio-organique, case 008, UA 488 du CNRS Université des Sciences et Techniques du Languedoc Place E. Bataillon, 34060, Montpellier-Cedex 1, France
&
J. L. Imbach Laboratoire de Chimie Bio-organique, case 008, UA 488 du CNRS Université des Sciences et Techniques du Languedoc Place E. Bataillon, 34060, Montpellier-Cedex 1, France
Pages 453-454 | Published online: 04 Oct 2006
 
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Abstract

A judicious use of HPLC allows to simplify the synthetic approach of an (oligo)nucleotide. As an example, is reported a preparation of an antiviral (3′-5′)dinucleotide with simultaneous isolation of its (3′-3′) isomer.

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