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Nucleosides and Nucleotides Volume 9, 1990 - Issue 3
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Chlorotetrolic Acid Ester as a Structural Probe of RNA

P. Roques Laboratoire de Biochimie Cellulaire, College de France, 11, pl. Marcelin Berthelot, 75231, Paris Cedex 05, France
&
M. Olomucki Laboratoire de Biochimie Cellulaire, College de France, 11, pl. Marcelin Berthelot, 75231, Paris Cedex 05, France
Pages 455-456 | Published online: 04 Oct 2006
 
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Abstract

Two isomeric tricyclic adenine derivatives can form by reaction of methyl 4—chloro-2—butynoate with single-stranded nucleic acids, depending on the degree of base stacking. An evaluation of the conformation of the polynucleotide can thus be easily performed.

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