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Original Articles

The Enzymatic Synthesis of Imidazole Deoxynucleosides: 1-β-D-2′-Deoxyribofuranosyl-5-aminoiinidazole-4-carboxamide and 1-β-D-2′-Deoxyribofuranosylbenzimidazole

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Pages 569-577 | Received 04 Dec 1989, Published online: 04 Oct 2006
 

Abstract

Nucleoside N-deoxyribosyl transferases (EC 2.4.2.6) from Lactobacillus leichmanii will catalyse the transfer of 2-deoxyribose from thymidine or 2′-deoxycytidine to 5-aminoimidazole-4-carboxamide or benzimidazole. 1-β-D-2′-Deoxyribofuranosyl-5-aminoimidazole-4-carboxamide and 1-0-D-2′-deoxyribofuranosyl-benzimidazole, respectively, are the only products which are formed.

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