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Nucleosides and Nucleotides Volume 9, 1990 - Issue 7
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Original Articles

The Synthesis of 2-Nitro-1-[(2-Hydroxyethoxy)Methyl]Imidazole (Azomycin Acyclonucleoside)

Prem C. Srivastava Health and Safety Research Division, Oak Ridge National Laboratory, Oak Ridge, TN, 37831-6022
&
Ahmad Hasan Health and Safety Research Division, Oak Ridge National Laboratory, Oak Ridge, TN, 37831-6022
Pages 899-905 | Received 06 Mar 1990, Published online: 04 Oct 2006
 
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Abstract

The synthesis of 2-nitro-1-[(2-hydroxyethoxy)methyl]imidazole, the acyclonucleoside analogue of antibiotic azomycin (azomycin acyclonucleoside), is accomplished via alkylation of azomycin with 2-benzoyloxyethoxymethylene chloride followed by debenzoylation.

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