Chemical and Biochemical Studies with Dithioate DNA

Marvin H. Caruthers Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO, 80309-0215

Graham Beaton Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO, 80309-0215

Lendell Cummins Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO, 80309-0215

Douglas Dellinger Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO, 80309-0215

Darla Graff Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO, 80309-0215

Yun-Xi Ma Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO, 80309-0215

William S. Marshall Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO, 80309-0215

Henri Sasmor Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO, 80309-0215

Paula Shankland Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO, 80309-0215

John Van Wu Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO, 80309-0215

Eric K. Yau Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO, 80309-0215

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Abstract

Dithioate DNA was synthesized and used for various biochemical studies. Results from these studies indicate that dithioate DNA is a potent inhibitor of HIV Reverse Transcriptase, activates endogenous RNase H in Hela cell nuclear extracts, and is a useful probe for studying protein-DNA interactions.

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Chemical and Biochemical Studies with Dithioate DNA

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Chemical and Biochemical Studies with Dithioate DNA

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