Assignment of Absolute Configuration at Phosphorus in Dithymidylyl(3′,5′)phosphormorpholidates and -Phosphormorpholidothioates

A. Wilk Centre of Molecular and Macromolecular Studies, Department of Bioorganic Chemistry, Sienkiewicza 112, 90-363, Lodz, Poland

B. Uzanski Centre of Molecular and Macromolecular Studies, Department of Bioorganic Chemistry, Sienkiewicza 112, 90-363, Lodz, Poland

W. J. Stec Centre of Molecular and Macromolecular Studies, Department of Bioorganic Chemistry, Sienkiewicza 112, 90-363, Lodz, Poland

Abstract

Diastereoisomers of dithymidylyl(3′,5′)phosphormorpholidate (1) and morpholidothioate 2 were isolated. Analysis of products of stereospecific reactions allowed us to correlate absolute configuration with RP HPLC=elution order - “fast”-eluted isomers are Sp, while “slow”-eluted are Rp isomers.

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Assignment of Absolute Configuration at Phosphorus in Dithymidylyl(3′,5′)phosphormorpholidates and -Phosphormorpholidothioates

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Assignment of Absolute Configuration at Phosphorus in Dithymidylyl(3′,5′)phosphormorpholidates and -Phosphormorpholidothioates

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